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Brightening

Niacinamide Vitamin B3

aging-vs-longevity-lv4
BrighteningFirmness / AgingBarrier
INCI: Niacinamide (Vitamin B3)
In short · TL;DR
Category
Brightening
Effect
Wrinkle improvement, melanin suppression, barrier strengthening, NAD+ precursor
Concentration
2-5% (MHLW approved)
Effect
Wrinkle improvement, melanin suppression, barrier strengthening, NAD+ precursor
Mechanism
NAD+ replenishment via salvage pathway → SIRT1 activation. NF-κB suppression. Melanosome transfer inhibition
Typical concentration
2-5% (MHLW approved)
Onset
Barrier: 2-4 weeks. Brightening: 8-12 weeks. Wrinkles: 12+ weeks
Cautions
Irritation at high concentrations (10% or above)
Evidence & references
Bissett et al. (2005) [PubMed], Hakozaki et al. (2002) [PubMed]
Journal

Related Journal

10
Skin-Concern SolutionsFor Those Who See No Change from Brightening Products -- The Real Causes of Dull SkinSkin-Concern SolutionsFor Those Who See No Results from Expensive Serums -- Why Price Doesn't Equal EffectivenessWhat “Suits Your Skin” MeansThe scientific foundation of personalized skincareCare Guides by ConcernDark spot and dullness care — the mechanism of melanin and effective ingredientsCare Guides by ConcernPore and acne care — the 3 factors of sebum, keratinization, and inflammationSkincare FundamentalsThe Correct Skincare Order — Why This Sequence MattersThe Complete Peptide GuidePeptide effective concentrations and the penetration challengeThe Complete Vitamin C GuideVitamin C x other ingredients -- synergies and contraindicationsAnti-Aging vs LongevityMost anti-aging ingredients are "symptomatic treatment"—the difference from fundamental careAnti-Aging vs LongevityWhy "fighting back" fails—from the perspective of cellular senescence and SASP
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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