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Peptides

FGF (Fibroblast Growth Factor)

exosome-trend-check
Firmness / AgingMoisturizing
In short · TL;DR
Category
Peptides
Effect
Dermal fibroblast proliferation promotion, collagen and elastin synthesis promotion
Concentration
0.0001-0.001%
Effect
Dermal fibroblast proliferation promotion, collagen and elastin synthesis promotion
Mechanism
Fibroblast growth factor. Binds to FGF receptor → Activates dermal fibroblasts → Promotes collagen, elastin, and hyaluronic acid synthesis. While EGF acts on the epidermis, FGF acts on the dermis
Typical concentration
0.0001-0.001%
Onset
Firmness and elasticity improvement: 8-12 weeks
Cautions
Like EGF, large molecular weight limits transdermal absorption. Quality variation issues with topical application of natural growth factors. Chemically synthesized peptides (such as Oligopeptide-24) were designed as alternatives to EGF/FGF for this reason
Evidence & references
Extensive research in regenerative medicine. Large-scale RCTs as cosmetics are limited
Journal

Related Journal

5
The Complete Peptide GuideNext-generation peptides -- synthetic biology and drug delivery frontiersSkin Longevity SeriesIs PDRN (Salmon DNA) the Real Deal? Grading Regenerative Buzz Ingredients with ScienceSkin Longevity SeriesThe Three Dermal Pillars — Collagen, Elastin and Hyaluronic AcidSkin Longevity SeriesA Century of Beauty ResearchSkin Longevity SeriesTrend Check: The Real Power of Exosome Cosmetics
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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