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Moisturizing & Barrier

Dipotassium Glycyrrhizate

MoisturizingBarrierSoothing
INCI: Dipotassium Glycyrrhizate
In short · TL;DR
Category
Moisturizing & Barrier
Effect
Anti-inflammatory, skin roughness prevention
Concentration
Japanese quasi-drug precedents (MHLW list): lotion 0.05–0.5%, cream/milk 0.05–0.2%, sunscreen 0.05%. Cosmetic use up to 1% (CIR 2007).
Effect
Anti-inflammatory, skin roughness prevention
Mechanism
Derived from licorice. Phospholipase A2 inhibition → Arachidonic acid cascade suppression
Typical concentration
Japanese quasi-drug precedents (MHLW list): lotion 0.05–0.5%, cream/milk 0.05–0.2%, sunscreen 0.05%. Cosmetic use up to 1% (CIR 2007).
Onset
The timeframe for soothing effects is not confirmed by primary sources.
Cautions
A well-established safe ingredient
Evidence & references
MHLW active-ingredient list / CIR 2007 https://pubmed.ncbi.nlm.nih.gov/17613133/ (checked 2026-10-20)
Journal

Related Journal

4
Skin Longevity SeriesThe Lens of Evidence Concentration — The Line Between "Contains" and "Works"Skin Longevity SeriesThe Science of Summer Acne—Sweat, Sebum, Clogged Pores, and the Ecology of C. acnesSkin Longevity SeriesThe 3-Day Obon Reset ── A Concentrated Rest Protocol for Sun-Tired SkinSkin Longevity SeriesThe Season-Change Switch: How the Autonomic Nervous System and the Skin Barrier Move Together
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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