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Stem Cell & Culture

Polydeoxyribonucleotide (PDRN)

2027-manifesto
Firmness / Aging
INCI: Polydeoxyribonucleotide (Sodium Salt)
In short · TL;DR
Category
Stem Cell & Culture
Effect
Tissue regeneration promotion, anti-inflammatory, collagen synthesis promotion, wound healing
Concentration
0.01-1% in cosmetics (1,000-10,000 ppm)
Effect
Tissue regeneration promotion, anti-inflammatory, collagen synthesis promotion, wound healing
Mechanism
Salmon testis-derived DNA fragment. Binds to A2A purine receptors → VEGF production promotion → Angiogenesis → Tissue regeneration. Anti-inflammatory action (TNF-α suppression). Fibroblast proliferation promotion. Also used as the main component in Rejuran injection in aesthetic medicine
Typical concentration
0.01-1% in cosmetics (1,000-10,000 ppm)
Onset
Skin elasticity improvement: 4-8 weeks. Faster with injection
Cautions
Caution for fish allergy as it is salmon-derived. Significant difference in penetration and efficacy between injection and topical application. Clinical data for topical use is less abundant than for injection
Evidence & references
Squadrito et al. (2017) "PDRN regenerative medicine" PubMed
Journal

Related Journal

8
Skin Longevity SeriesRe-examining the "28-Day Turnover" Myth Through ScienceSkin Longevity SeriesCeramide, the Protagonist — The Science of the Lipid That Binds the SkinSkin Longevity SeriesIs PDRN (Salmon DNA) the Real Deal? Grading Regenerative Buzz Ingredients with ScienceSkin Longevity SeriesDesigning Moisture in Layers — Humectant, Occlusive, EmollientSkin Longevity SeriesThe Three Dermal Pillars — Collagen, Elastin and Hyaluronic AcidSkin Longevity SeriesTrend Check: The Real Power of Exosome CosmeticsSkin Longevity Series[Trend Check] The 2026 Buzz-Ingredient ReckoningSkin Longevity SeriesA 2027 Manifesto: The Next Step for Skin Longevity
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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