HOME ／ Ingredients ／ Peptides
Peptides
Palmitoyl Tripeptide-38
MoisturizingFirmness / Aging
INCI: Palmitoyl Tripeptide-38
In short · TL;DR
Category
Peptides
Effect
A peptide used to support skin firmness. Increased collagen and hyaluronic acid production has been reported in cultured cells.
Concentration
The raw material Matrixyl synthe'6 contains 0.025% of the peptide (Coty patent). The pure-peptide level in a product is "raw-material percentage × 0.025%": 2% raw material gives 0.0005% (5 ppm), 4% gives 0.001%. The manufacturer's recommended use level is not confirmed in primary sources.
Effect
A peptide used to support skin firmness. Increased collagen and hyaluronic acid production has been reported in cultured cells.
Mechanism
Sequence: Pal-Lys-Met(O2)-Lys (methionine in the dioxidised form; Sederma patent). In cultured fibroblasts, collagen I rose +188% at 4 ppm; in keratinocytes, hyaluronic acid rose +290% at 6 ppm and laminins also increased (all cell-culture values).
Typical concentration
The raw material Matrixyl synthe'6 contains 0.025% of the peptide (Coty patent). The pure-peptide level in a product is "raw-material percentage × 0.025%": 2% raw material gives 0.0005% (5 ppm), 4% gives 0.001%. The manufacturer's recommended use level is not confirmed in primary sources.
Onset
The manufacturer (Croda) reports a clinical result on forehead and crow's-feet wrinkles after 2 months, without stating the number of subjects or a control group. Independent peer-reviewed clinical data are unconfirmed.
Cautions
Designed with dioxidised methionine for improved stability (patent).
Evidence & references
US9149659B2 (0.025% in raw material) / US8697656B2 (sequence, cell-culture values) / Croda (manufacturer data) (checked 2026-10-20)
Journal
Related Journal
2This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
← Back to Ingredients