Human Blood-Derived Natural Killer Cell Conditioned Culture Media Extract

Senescent cell clearance (senolysis), anti-inflammatory, immune modulation, collagen production promotion, enhanced skin regeneration

Culture supernatant containing cytokines produced by NK cells (IFN-γ, TNF-α, granzyme B, perforin, etc.) induces apoptosis in senescent fibroblasts. Suppresses SASP (senescence-associated secretory phenotype) and reduces chronic inflammation. Indirectly promotes collagen and elastin synthesis in surrounding healthy cells

Stock solution 1-5%. Effective cytokine concentration in culture medium depends on manufacturing conditions

Anti-inflammatory effect: several days to 1 week. Skin quality improvement: 4-8 weeks. Structural improvement from senescent cell clearance: 8-12 weeks

Derived from human blood, so donor screening and quality control are critical. Ensuring cytokine profile uniformity between manufacturing lots is a challenge. Refrigerated storage recommended. Potential synergistic effect when combined with other human-derived culture media (stem cell supernatant, etc.)

Basic research on senolytic function of NK cells (Nat Med, Cell, etc.). In vitro data on senescent fibroblast clearance and collagen synthesis promotion for cosmetic applications