Hexadecyloxy PG Hydroxyethyl Hexadecanamide

BarrierMoisturizing

INCI: Hexadecyloxy PG Hydroxyethyl Hexadecanamide

In short · TL;DR

Category

Moisturizing

Effect

A synthetic lipid resembling natural ceramides that supplements the barrier-like structure of the stratum corneum.

Concentration

Depends on the level used (usually less than 1% to a few %).

Effect

A synthetic lipid resembling natural ceramides that supplements the barrier-like structure of the stratum corneum.

Mechanism

A synthetic ceramide analogue whose amide structure and alkyl chains mimic the lamellar structure of the intercellular lipids of the stratum corneum, contributing to moisture retention and barrier support.

Typical concentration

Depends on the level used (usually less than 1% to a few %).

Onset

Improved feel is immediate; barrier indices come with continued use.

Cautions

The permitted level and solubility require formulation-level consideration.

Evidence & references

参考文献: Skin-Protective Performance of Alternative Stratum Corneum Formed by a Pseudo-Ceramide-Containing Steroid Lamellar Cream（PubMed PMID:40066914 https://pubmed.ncbi.nlm.nih.gov/40066914/）

This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.

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