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Exfoliation

Gluconolactone

SoothingExfoliation / PoresAntioxidantBrightening
INCI: Gluconolactone
In short · TL;DR
Category
Exfoliation
Effect
A PHA (polyhydroxy acid) that softens old stratum corneum.
Concentration
Cosmetic use up to 15% (CIR 2022, leave-on).
Effect
A PHA (polyhydroxy acid) that softens old stratum corneum.
Mechanism
Lactone structure for sustained release, antioxidant + gentle turnover
Typical concentration
Cosmetic use up to 15% (CIR 2022, leave-on).
Onset
One study used a 5% serum for 30 days on rosacea redness (Peng 2025).
Cautions
A repeated patch test of a 15% product (106 people) showed no irritation or sensitisation. In an acne study of a 14% lotion, about 24% reported some discomfort (not significantly different from placebo). For rosacea, get diagnosis and treatment from a dermatologist.
Evidence & references
CIR Glycolactones 2022 / Peng 2025 https://pubmed.ncbi.nlm.nih.gov/40111222/ (checked 2026-10-20)
Journal

Related Journal

2
Skin Longevity SeriesRe-examining the "28-Day Turnover" Myth Through ScienceSkin Longevity SeriesA Century of Beauty Research
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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