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Antioxidant

Fisetin

2027-manifesto
AntioxidantSoothing
INCI: Fisetin
In short · TL;DR
Category
Antioxidant
Effect
Selective senolytic, SIRT1 activator, anti-inflammatory
Concentration
0.1-0.5%
Effect
Selective senolytic, SIRT1 activator, anti-inflammatory
Mechanism
p53/p21-dependent apoptosis of senescent cells. Bcl-2 inhibition
Typical concentration
0.1-0.5%
Onset
8 weeks for SASP reduction, skin clarity
Cautions
Oxidation-sensitive, pair with antioxidants
Evidence & references
EBioMedicine 2018: identified as most potent senolytic
Journal

Related Journal

3
Skin Longevity SeriesChoosing Skin Longevity: The Pledge KAIAN Makes This JulySkin Longevity SeriesA Century of Beauty ResearchSkin Longevity SeriesA 2027 Manifesto: The Next Step for Skin Longevity
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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