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EGF (Epidermal Growth Factor)

exosome-trend-check
Exfoliation / PoresFirmness / Aging
In short · TL;DR
Category
Peptides
Effect
Epidermal cell proliferation promotion, wound healing, turnover normalization
Concentration
0.0001-0.001% (active at very low concentrations)
Effect
Epidermal cell proliferation promotion, wound healing, turnover normalization
Mechanism
Epidermal growth factor. A polypeptide consisting of 53 amino acids. Binds to EGF receptor (EGFR) → Tyrosine kinase activation → Activates cell proliferation signal cascade (Ras/MAPK pathway). Nobel Prize-winning ingredient (1986, Dr. Stanley Cohen)
Typical concentration
0.0001-0.001% (active at very low concentrations)
Onset
Turnover improvement: 4-6 weeks
Cautions
Extremely limited transdermal absorption due to large molecular weight (6,045 Da). Quality varies between recombinant (gene recombination) and chemical synthesis methods. Name was changed from 'Human Oligopeptide-1' in Japan due to safety concerns (risk of excessive cell proliferation)
Evidence & references
Primary peer-reviewed source to be verified
Journal

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6
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This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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