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Cholesterol

winter-lipid-balance
BarrierMoisturizing
INCI: Cholesterol
In short · TL;DR
Category
Oils & Lipids
Effect
Constitutes stratum corneum intercellular lipids and helps repair barrier function.
Concentration
Loading-dependent (usually under 1% to a few percent).
Effect
Constitutes stratum corneum intercellular lipids and helps repair barrier function.
Mechanism
One of the three major lipids that, together with ceramides and free fatty acids, form the stratum corneum lamellar structure; loading at a physiological ratio is said to contribute to barrier recovery.
Typical concentration
Loading-dependent (usually under 1% to a few percent).
Onset
Improvement in barrier indices with continued use.
Cautions
In formulation design, the ratio with ceramides and fatty acids is important.
Evidence & references
https://pubchem.ncbi.nlm.nih.gov/compound/5997
Journal

Related Journal

9
Skin-Concern SolutionsFor Those Who Feel Cream Alone Isn't Enough -- What Needs to Happen Before You "Seal"Skin Structure & ScienceStratum corneum barrier function -- the brick and mortar modelSkin Longevity CarePracticing Skin Longevity with ingredients—morning and night routinesSkin Longevity CareQuantitative evaluation and personalized protocol design for Skin LongevitySeasonal & Environmental SkincareWinter skincare — protecting your barrier in a 30% humidity worldSeasonal & Environmental SkincareAdaptive skincare design — the science behind personalized ampoulesSkin Longevity SeriesThe Invisible Dryness Under Air Conditioning — The Science of TEWL and Barrier FunctionSkin Longevity SeriesCeramide, the Protagonist — The Science of the Lipid That Binds the SkinSkin Longevity SeriesLipid Balance in Deep Winter: Designing Skin's Oils from Inside and Out
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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