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Plant Extracts

CICA Centella Asiatica Extract

SoothingBarrier
INCI: Centella Asiatica Extract
In short · TL;DR
Category
Plant Extracts
Effect
Anti-inflammatory, wound healing, barrier repair
Concentration
Cosmetic use up to 0.5% (CIR 2015, leave-on face and neck products).
Effect
Anti-inflammatory, wound healing, barrier repair
Mechanism
Asiaticoside, madecassoside, etc. activate the TGF-β pathway
Typical concentration
Cosmetic use up to 0.5% (CIR 2015, leave-on face and neck products).
Onset
Timeframes for soothing or barrier effects are not confirmed by primary sources.
Cautions
Several cases of contact dermatitis from ointments and creams have been reported, and some people tested positive at 1% in patch tests. CIR considers sensitisation concern low at 0.5% or less.
Evidence & references
CIR Centella 2015 / Bylka 2014 https://pubmed.ncbi.nlm.nih.gov/24399761/ (checked 2026-10-20)
Journal

Related Journal

5
Skin Longevity CareMolecular targets of Longevity care—understanding what you’re caring forAesthetic Medicine vs Home CareEssential home care during aesthetic medicine "downtime"Skin Longevity SeriesThe Science of Summer Acne—Sweat, Sebum, Clogged Pores, and the Ecology of C. acnesSkin Longevity SeriesThe 3-Day Obon Reset ── A Concentrated Rest Protocol for Sun-Tired SkinSkin Longevity SeriesThe Season-Change Switch: How the Autonomic Nervous System and the Skin Barrier Move Together
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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