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Base & Functional
Caffeine
Antioxidant
INCI: Caffeine
In short · TL;DR
Category
Base & Functional
Effect
The human study on under-eye dark circles and puffiness tested a cream combining caffeine with a vitamin C derivative, peptides and others (12 weeks, no control group, 37 completed). The effect of caffeine alone is unconfirmed.
Concentration
Primary data on a use level are unconfirmed.
Effect
The human study on under-eye dark circles and puffiness tested a cream combining caffeine with a vitamin C derivative, peptides and others (12 weeks, no control group, 37 completed). The effect of caffeine alone is unconfirmed.
Mechanism
A methylxanthine. Antioxidant action and involvement in local circulation and lipolysis pathways are reported.
Typical concentration
Primary data on a use level are unconfirmed.
Cautions
CIR concluded it is safe in current practices of use (2024).
Evidence & references
https://pubmed.ncbi.nlm.nih.gov/38112168/ (combination formula, open-label) / CIR 2024 https://pubmed.ncbi.nlm.nih.gov/39049435/ (checked 2026-10-20)
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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