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Moisturizing & Barrier

Allantoin

MoisturizingBarrierSoothingFirmness / Aging
INCI: Allantoin
In short · TL;DR
Category
Moisturizing & Barrier
Effect
Anti-inflammatory, wound healing promotion, skin roughness prevention, stratum corneum softening
Concentration
Japanese quasi-drug precedents (MHLW list): lotion 0.05–0.2%, cream/milk 0.05–0.5%. Cosmetic use up to 2% has been reported (CIR 2010).
Effect
Anti-inflammatory, wound healing promotion, skin roughness prevention, stratum corneum softening
Mechanism
Comfrey-derived ingredient. Promotes cell proliferation and accelerates tissue repair. Anti-irritant action to calm sensitive and post-inflammatory skin. Promotes water binding in the stratum corneum
Typical concentration
Japanese quasi-drug precedents (MHLW list): lotion 0.05–0.2%, cream/milk 0.05–0.5%. Cosmetic use up to 2% has been reported (CIR 2010).
Onset
Timeframes for soothing or roughness changes are not confirmed by primary sources.
Cautions
Extremely high safety. Suitable for virtually all skin types
Evidence & references
MHLW active-ingredient list / CIR 2010 https://pubmed.ncbi.nlm.nih.gov/20448269/ (checked 2026-10-20)
Journal

Related Journal

3
Skin Longevity SeriesThe Invisible Dryness Under Air Conditioning — The Science of TEWL and Barrier FunctionSkin Longevity SeriesThe 3-Day Obon Reset ── A Concentrated Rest Protocol for Sun-Tired SkinSkin Longevity SeriesThe Season-Change Switch: How the Autonomic Nervous System and the Skin Barrier Move Together
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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