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Argireline (Acetyl Hexapeptide-8)

Firmness / Aging
INCI: Acetyl Hexapeptide-8
In short · TL;DR
Category
Peptides
Effect
Expression wrinkle reduction
Concentration
The study used an emulsion containing 10% of the hexapeptide (Blanes-Mira 2002). Primary data on product use levels are unconfirmed.
Effect
Expression wrinkle reduction
Mechanism
SNAP-25 SNARE complex formation inhibition
Typical concentration
The study used an emulsion containing 10% of the hexapeptide (Blanes-Mira 2002). Primary data on product use levels are unconfirmed.
Onset
In a study using a 10% emulsion for 30 days, wrinkle depth decreased by up to 30% (number of subjects not stated in the abstract).
Cautions
The study measured wrinkle depth only; no study measuring sagging was found.
Evidence & references
Blanes-Mira 2002 https://pubmed.ncbi.nlm.nih.gov/18498523/ (checked 2026-10-20)
Journal

Related Journal

2
The Complete Peptide GuideFour types of peptides -- signal, neuro, carrier, and enzyme-inhibitingSkin Longevity SeriesA Century of Beauty Research
This page is reference information and does not guarantee efficacy. Figures vary by test conditions (in vitro / manufacturer / concentration). It does not indicate pharmaceutical efficacy.
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